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一種蛋白質可能有助防止輻射傷害


www.erchengauto.com 來源:新華網  日期:2019-06-12

  西班牙研究人員日前在美國《科學》雜志上發表報告說,提升體內一種蛋白質的水平可保護胃腸道免受輻射傷害。這一發現不僅可以減少放射療法給癌癥患者帶來的副作用,還有望用于保護核災難受害者以及宇航員的健康。
 
  放射療法通過高能量輻射定點照射來抑制癌細胞的生長,但同時也會傷害到健康細胞,有時會誘發胃腸道綜合征甚至導致死亡。
 
  西班牙國家癌癥研究中心等機構的研究人員通過實驗鼠實驗發現,在經受高劑量輻射后,體內一種名為URI的蛋白質含量高的實驗鼠并不會出現胃腸道綜合征,可全部存活;體內這種蛋白質含量正常的普通實驗鼠則有70%會死于胃腸道綜合征;而體內這種蛋白質含量較低的實驗鼠則全部死于胃腸道綜合征。
 
  研究人員表示,雖然目前對URI蛋白質的功能尚未完全理解,但他們發現了這種蛋白質保護細胞不受輻射損害的機制。URI蛋白質在一種位于腸隱窩中的休眠干細胞群中被表達。在這種干細胞群表達URI蛋白質時,這些細胞不會增殖,因此不會受到放射侵害,因為放射只影響增殖細胞。而當干細胞群中不存在這種蛋白質時,致癌基因過度表達引發細胞增殖,從而導致細胞對放射損傷敏感,繼而導致細胞死亡。
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